In this two-quarter series, students are introduced through didactic instruction, workshops, and clinical case discussions to the basic physiologic principles that underlie the normal function of the various organs and organ systems. These core principles provide the foundation through which the student develops an understanding of the physiologic adaptations and transitions that occur in commonly occurring disease states. Emphasis is given to developing an understanding of health in physiologic terms and appreciation of the diverse regulatory processes that maintain the homeostasis of the human body.