This course is designed to expand students’ knowledge of research in basic cardiovascular sciences. The novel experimental pre-clinical/translational concepts related to cardiac and vascular pathophysiology and potential drug target(s), along with proposed mechanism of action, if applicable, are covered. The course focuses on analysis of complex pathologic mechanism(s), including dysregulated signaling, inflammation, oxidative stress and myocardial remodeling, underlying arrhythmia, myocardial ischemia and heart failure, as well as evaluation of new/promising pharmacological intervention(s). The format of the course includes lectures and active participation in research article-based discussions, to produce student-developed evaluation and conclusions, in combined format of oral presentation and written summary of each discussed/presented topic information.