This course presents the biophysics, functional properties, and regulation of membrane transport, excitable cells, skeletal muscle, cardiovascular and respiratory systems. A discussion of circulatory fluid dynamics, peripheral vascular tone, blood pressure, and electrical and mechanical activity of the heart is included in the cardiovascular section of the course. Small group case discussions, workshops and simulations facilitate development of critical thinking and problem-solving skills as students using use basic physiologic concepts to understand the pathogenesis of signs and symptoms in specific case studies.