This is the first in the series of three courses that explore the technology, techniques, and issues associated with cardiovascular perfusion and how the extracorporeal circuit is used in today’s healthcare setting. This course provides an overview of the evolution of cardiopulmonary bypass, an introduction to the operating room and its environment including sterile technique, blood-borne pathogens, personal protection equipment, and an in-depth look at the components that comprise the extracorporeal circuit.